NBR1 antibody (AA 1-665) (PE)

Catalog No. ABIN8014204

The PE-conjugated Rabbit Polyclonal anti-NBR1 antibody (ABIN8014204) specifically detects NBR1 in FACS. The antibody is reactive with Human and Monkey samples.

Quick Overview for NBR1 antibody (AA 1-665) (PE) (ABIN8014204)

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NBR1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-NBR1 Antibody (PE)

Binding Specificity: AA 1-665

Purpose: Anti-NBR1 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NBR1 recombinant protein (Position: M1-H665).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Alternative Name: NBR1

Background:

Background: Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: NBR1 autophagy cargo receptor

Gene ID: 4077

UniProt: Q14596

Pathways: Autophagy