Neurexin 1 antibody (AA 141-294) (HRP)

Catalog No. ABIN8014565

This Rabbit Polyclonal antibody specifically detects Neurexin 1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for Neurexin 1 antibody (AA 141-294) (HRP) (ABIN8014565)

Target: Neurexin 1 (NRXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurexin 1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Neurexin 1 Antibody (HRP)

Binding Specificity: AA 141-294

Purpose: Anti-Neurexin 1/NRXN1 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neurexin 1

Target: Neurexin 1 (NRXN1)

Alternative Name: NRXN1

Background:

Background: Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Gene Full Name: neurexin 1

Gene ID: 9378

UniProt: P58400

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development