NXPH3 antibody (AA 5-217) (HRP)

Catalog No. ABIN8014598

This Rabbit Polyclonal antibody specifically detects NXPH3 in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NXPH3 antibody (AA 5-217) (HRP) (ABIN8014598)

Target: NXPH3 (Neurexophilin 3 (NXPH3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NXPH3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-NXPH3 Antibody (HRP)

Binding Specificity: AA 5-217

Purpose: Anti-NXPH3 Antibody HRP Conjugated

Predicted Reactivity: Human NXPH3 shares 95.8% amino acid (aa) sequence identity with mouse,rat NXPH3,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NXPH3 recombinant protein (Position: R5-K217). Human NXPH3 shares 95.8% amino acid (aa) sequence identity with mouse and rat NXPH3, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NXPH3

Target: NXPH3 (Neurexophilin 3 (NXPH3))

Alternative Name: NXPH3

Background:

Background: Neurexophilin-3 is a protein that in humans is encoded by the NXPH3 gene. Neurexophilin-3 (NXPH-3) is a neuropeptide-like secreted glycoprotein in the neurexophilin family. The 252 amino acid (aa) NXPH-3 precursor contains a 22 aa signal peptide, plus a 230 aa proprecursor that is likely cleaved at a basic motif, producing a 76 aa propeptide and a 154 aa mature protein. Mature rat NXPH-3 shares 99 % , 95 % and 92 % aa identity with mouse, human and bovine NXPH-3, respectively. It contains motifs that are conserved among all neurexophilins, including three potential N-glycosylation sites in the N-terminal portion and six cysteines in the C-terminal portion. NXPH-3 is expressed selectively in subplate-derived neurons in the cortex, granule cells in the vestibulocerebellum, and Cajal-Retzius cells during development. NXPH-1 is the neurexophilin most similar to NXPH-3, sharing 69 % aa identity within the mature region. Expression of NXPH-1 and NXPH-3 does not appear to overlap, with NXPH-1 expression occurring mainly by cells that resemble inhibitory interneurons. Both are tightly bound extracellular ligands of alpha -neurexins, synaptic transmembrane molecules that are essential for calcium-triggered neurotransmitter release. Genetic deletion of NXPH-1 and/or NXPH-3 produces no anatomical effect, although mice lacking NXPH-3 show specific defects in motor coordination. Of the other known neurexophilins, NXPH-2 is not expressed in rodents, and NXPH-4 does not bind alpha -neurexins.

Gene Full Name: neurexophilin 3

Gene ID: 11248

UniProt: O95157