Neurocan antibody (C-Term) (Fluoro594)

Catalog No. ABIN8014651

The Fluoro594-conjugated Rabbit Polyclonal anti-Neurocan antibody (ABIN8014651) specifically detects Neurocan in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Neurocan antibody (C-Term) (Fluoro594) (ABIN8014651)

Target: Neurocan (NCAN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurocan antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-Neurocan Antibody (Fluoro594)

Binding Specificity: C-Term

Purpose: Anti-Neurocan/NCAN Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Neurocan, which shares 90% amino acid (aa) sequence identity with both mouse and rat Neurocan.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Neurocan

Target: Neurocan (NCAN)

Alternative Name: NCAN

Background:

Background: Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Gene Full Name: neurocan

Gene ID: 1463

UniProt: O14594

Pathways: Glycosaminoglycan Metabolic Process