Neurocan antibody (AA 1140-1179)

Catalog No. ABIN8014668

The Rabbit Polyclonal anti-Neurocan antibody is suitable to detect Neurocan in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for Neurocan antibody (AA 1140-1179) (ABIN8014668)

Target: Neurocan (NCAN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurocan antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-Neurocan Antibody

Binding Specificity: AA 1140-1179

Purpose: Anti-Neurocan/NCAN Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Neurocan/NCAN Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Neurocan/NCAN recombinant protein (Position: H1140-A1179).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neurocan

Target: Neurocan (NCAN)

Alternative Name: NCAN

Background:

Background: Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Gene Full Name: neurocan

Molecular Weight: 142 kDa

Gene ID: 1463

UniProt: O14594

Pathways: Glycosaminoglycan Metabolic Process