Neurogranin antibody (AA 11-54)

Catalog No. ABIN8014800

The Rabbit Polyclonal anti-Neurogranin antibody is suitable to detect Neurogranin in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for Neurogranin antibody (AA 11-54) (ABIN8014800)

Target: Neurogranin (NRGN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogranin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-Neurogranin Antibody

Binding Specificity: AA 11-54

Purpose: Anti-Neurogranin/NRGN Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Neurogranin/NRGN Antibody. Tested in ELISA, Flow Cytometry, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NRGN recombinant protein (Position: K11-K54).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Neurogranin

Target: Neurogranin (NRGN)

Alternative Name: NRGN

Background:

Background: Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Gene Full Name: neurogranin

Molecular Weight: 11 kDa

Gene ID: 4900

UniProt: Q92686