NPBWR1 antibody (AA 58-328) (Fluoro550)

Catalog No. ABIN8015035

The Fluoro550-conjugated Rabbit Polyclonal anti-NPBWR1 antibody (ABIN8015035) specifically detects NPBWR1 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NPBWR1 antibody (AA 58-328) (Fluoro550) (ABIN8015035)

Target: NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPBWR1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-NPBWR1 Antibody (Fluoro550)

Binding Specificity: AA 58-328

Purpose: Anti-GPCR GPR7/NPBWR1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GPCR GPR7/NPBWR1 recombinant protein (Position: V58-A328).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NPBWR1

Target: NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))

Alternative Name: NPBWR1

Background:

Background: Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. In rodent models, NPBWR1 is over-expressed in Schwann cells associated with neuropathic pain, suggesting it inhibits inflammatory pain responses. Mice without NPBW1 exhibited a stronger hostile reaction to intruders, suggesting NPBW1 has a role in stress responses. Early studies indicated that NPB and NPW had a complex effect on appetite, but generally led to anorexia. Similarly, male rats lacking NPBWR1 exhibited hyperphagiaand adult-onset obesity, though why female rats are unaffected is unknown. Researchers speculated that activating these pathways might decrease obesity, and synthesized a small-molecule ligand that is capable of stimulating both receptors at low concentrations.

Gene Full Name: neuropeptides B and W receptor 1

Gene ID: 2831

UniProt: P48145