Neuropilin 1 antibody (AA 504-827) (HRP)

Catalog No. ABIN8015082

The Mouse Monoclonal anti-Neuropilin 1 antibody is suitable to detect Neuropilin 1 in samples from Human and Rat. It has been validated for WB, IHC and ELISA.

Quick Overview for Neuropilin 1 antibody (AA 504-827) (HRP) (ABIN8015082)

Target: Neuropilin 1 (NRP1)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuropilin 1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4G3F7

Product Details anti-Neuropilin 1 Antibody (HRP)

Binding Specificity: AA 504-827

Purpose: Anti-Neuropilin 1 Antibody (monoclonal, 4G3F7) HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human Neuropilin 1 shares 95%,94% amino acid (aa) sequences identity with mouse,rat Neuropilin 1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Neuropilin 1 recombinant protein (Position: K504-T827). Human Neuropilin 1 shares 95% and 94% amino acid (aa) sequences identity with mouse and rat Neuropilin 1, respectively.

Isotype: IgG2b

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neuropilin 1

Target: Neuropilin 1 (NRP1)

Alternative Name: NRP1

Background:

Background: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contain a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors, they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene Full Name: neuropilin 1

Gene ID: 8829

UniProt: O14786

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals