NSMCE4A antibody (AA 69-380) (FITC)

Catalog No. ABIN8016071

This Rabbit Polyclonal antibody specifically detects NSMCE4A in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NSMCE4A antibody (AA 69-380) (FITC) (ABIN8016071)

Target: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NSMCE4A antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-NSMCE4A Antibody (FITC)

Binding Specificity: AA 69-380

Purpose: Anti-NSMCE4A Antibody FITC Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NSMCE4A recombinant protein (Position: D69-Q380).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NSMCE4A

Target: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Alternative Name: NSMCE4A

Background:

Background: Non-SMC element 4 homolog A is a protein that in humans is encoded by the NSMCE4A gene. NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.

Gene Full Name: NSE4A component of SMC5/6 complex

Gene ID: 54780

UniProt: Q9NXX6

Pathways: Positive Regulation of Response to DNA Damage Stimulus