NPLOC4 antibody (AA 1-495) (Fluoro550)

Catalog No. ABIN8016708

The Rabbit Polyclonal anti-NPLOC4 antibody is suitable to detect NPLOC4 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for NPLOC4 antibody (AA 1-495) (Fluoro550) (ABIN8016708)

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPLOC4 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-NPLOC4 Antibody (Fluoro550)

Binding Specificity: AA 1-495

Purpose: Anti-NPL4/NPLOC4 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NPL4/NPLOC4 recombinant protein (Position: M1-N495).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NPLOC4

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Alternative Name: NPLOC4

Background:

Background: Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene. Nuclear protein localization protein 4 (NPL4, NPLOC4) was originally identified as a yeast nuclear transport protein that was later recognized as a critical component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Mammalian NPL4 protein has an amino-terminal ubiquitin-like domain containing a p97 binding site, and a conserved carboxy-terminal zinc finger (NZF) motif responsible for binding ubiquitinated target proteins. NPL4 binds ubiquitin fusion degradation protein 1 (UFD1) to form a heterodimer that associates with the p97 AAA-ATPase, creating a protein complex that mediates delivery of ubiquitinated ER proteins to the proteasome.

Gene Full Name: NPL4 homolog, ubiquitin recognition factor

Gene ID: 55666

UniProt: Q8TAT6