NCOA2 antibody (AA 297-1071) (Fluoro594)

Catalog No. ABIN8016797

This Rabbit Polyclonal antibody specifically detects NCOA2 in FACS. It exhibits reactivity toward Human.

Quick Overview for NCOA2 antibody (AA 297-1071) (Fluoro594) (ABIN8016797)

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA2 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-NCOA2 Antibody (Fluoro594)

Binding Specificity: AA 297-1071

Purpose: Anti-NCOA2 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human NCOA2 shares 93.4%,90.8% amino acid (aa) sequence identity with mouse,rat NCOA2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071). Human NCOA2 shares 93.4% and 90.8% amino acid (aa) sequence identity with mouse and rat NCOA2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Alternative Name: NCOA2

Background:

Background: The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Gene Full Name: nuclear receptor coactivator 2

Gene ID: 10499

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling