OCRL antibody (AA 1-901) (Cy3)

Catalog No. ABIN8017917

The Rabbit Polyclonal anti-OCRL antibody is suitable to detect OCRL in samples from Human. It has been validated for FACS.

Quick Overview for OCRL antibody (AA 1-901) (Cy3) (ABIN8017917)

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OCRL antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-OCRL Antibody (Cy3)

Binding Specificity: AA 1-901

Purpose: Anti-OCRL Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OCRL recombinant protein (Position: M1-D901).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for OCRL

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Alternative Name: OCRL

Background:

Background: Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans. This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.

Gene Full Name: OCRL inositol polyphosphate-5-phosphatase

Gene ID: 4952

UniProt: Q01968

Pathways: Inositol Metabolic Process