OCRL antibody (AA 1-901)

Catalog No. ABIN8017926

The Rabbit Polyclonal anti-OCRL antibody is suitable to detect OCRL in samples from Human. It has been validated for WB, ELISA, IHC, IF and ICC.

Quick Overview for OCRL antibody (AA 1-901) (ABIN8017926)

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OCRL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Grade: Carrier-free

Product Details anti-OCRL Antibody

Binding Specificity: AA 1-901

Purpose: Anti-OCRL Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-OCRL Antibody. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OCRL recombinant protein (Position: M1-D901).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for OCRL

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Alternative Name: OCRL

Background:

Background: Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans. This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.

Gene Full Name: OCRL inositol polyphosphate-5-phosphatase

Molecular Weight: 104 kDa

Gene ID: 4952

UniProt: Q01968

Pathways: Inositol Metabolic Process