OPTN antibody (AA 241-577) (Fluoro647)

Catalog No. ABIN8018277

The Mouse Monoclonal anti-OPTN antibody is suitable to detect OPTN in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for OPTN antibody (AA 241-577) (Fluoro647) (ABIN8018277)

Target: OPTN (Optineurin (OPTN))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This OPTN antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Clone: 3D8

Product Details anti-OPTN Antibody (Fluoro647)

Binding Specificity: AA 241-577

Purpose: Anti-Optineurin/OPTN Antibody (monoclonal, 3D8) Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse,rat Optineurin.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: OPTN

Background:

Background: OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Full Name: optineurin

Gene ID: 10133

UniProt: Q96CV9

Pathways: M Phase