Osteocalcin antibody (AA 50-99) (Biotin)

Catalog No. ABIN8018513

This Rabbit Polyclonal antibody specifically detects Osteocalcin in IHC, WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for Osteocalcin antibody (AA 50-99) (Biotin) (ABIN8018513)

Target: Osteocalcin (BGLAP)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Osteocalcin antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Product Details anti-Osteocalcin Antibody (Biotin)

Binding Specificity: AA 50-99

Purpose: Anti-Osteocalcin/BGLAP Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived rat Osteocalcin recombinant protein (Position: Y50-V99). Rat Osteocalcin shares 80.9%,68.9% amino acid (aa) sequence identity with human,mouse Osteocalcin,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived rat Osteocalcin recombinant protein (Position: Y50-V99). Rat Osteocalcin shares 80.9% and 68.9% amino acid (aa) sequence identity with human and mouse Osteocalcin, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Osteocalcin

Target: Osteocalcin (BGLAP)

Alternative Name: Bglap

Background:

Background: Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. It acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time ing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. Also, it may play a role in male fertility. And it is found that picomolar amounts of osteocalcin affected insulin secretion and beta-cell proliferation.

Gene Full Name: bone gamma-carboxyglutamate protein

Gene ID: 25295

UniProt: P04640