OTUD5 antibody (AA 168-555) (Fluoro488)

Catalog No. ABIN8018636

This Rabbit Polyclonal antibody specifically detects OTUD5 in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for OTUD5 antibody (AA 168-555) (Fluoro488) (ABIN8018636)

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD5 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-OTUD5 Antibody (Fluoro488)

Binding Specificity: AA 168-555

Purpose: Anti-OTUD5 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human OTUD5 shares 98.2%,98.5% amino acid (aa) sequence identity with mouse,rat OTUD5,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OTUD5 recombinant protein (Position: R168-D555). Human OTUD5 shares 98.2% and 98.5% amino acid (aa) sequence identity with mouse and rat OTUD5, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for OTUD5

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Alternative Name: OTUD5

Background:

Background: OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Full Name: OTU deubiquitinase 5

Gene ID: 55593

UniProt: Q96G74