HRPT2 antibody (AA 119-520) (APC)

Catalog No. ABIN8019457

The APC-conjugated Rabbit Polyclonal anti-HRPT2 antibody (ABIN8019457) specifically detects HRPT2 in FACS. The antibody is reactive with Human samples.

Quick Overview for HRPT2 antibody (AA 119-520) (APC) (ABIN8019457)

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRPT2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-HRPT2 Antibody (APC)

Binding Specificity: AA 119-520

Purpose: Anti-HRPT2/CDC73 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human HRPT2 shares 100%,99.8% amino acid (aa) sequence identity with mouse,rat HRPT2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HRPT2 recombinant protein (Position: Q119-R520). Human HRPT2 shares 100% and 99.8% amino acid (aa) sequence identity with mouse and rat HRPT2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HRPT2

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Alternative Name: CDC73

Background:

Background: Cell division cycle 73, also known as HRPT2, is a protein which in humans is encoded by the CDC73 gene. This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. And this protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.

Gene Full Name: cell division cycle 73

Sequence Similarities: Belongs to the CDC73 family.

Gene ID: 79577

UniProt: Q6P1J9

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance