Patched 2 antibody (Middle Region) (Cy3)

Catalog No. ABIN8019759

The Rabbit Polyclonal anti-Patched 2 antibody is suitable to detect Patched 2 in samples from Human. It has been validated for FACS.

Quick Overview for Patched 2 antibody (Middle Region) (Cy3) (ABIN8019759)

Target: Patched 2 (PTCH2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Patched 2 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-Patched 2 Antibody (Cy3)

Binding Specificity: Middle Region

Purpose: Anti-PTCH2 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human PTCH2, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Patched 2

Target: Patched 2 (PTCH2)

Alternative Name: PTCH2

Background:

Background: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role forPtch2in adult epidermal homeostasis via Shh signaling.

Gene Full Name: patched 2

Gene ID: 8643

UniProt: Q9Y6C5

Pathways: Hedgehog Signaling