Patched 2 antibody (Middle Region) (HRP)

Catalog No. ABIN8019764

This Rabbit Polyclonal antibody specifically detects Patched 2 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for Patched 2 antibody (Middle Region) (HRP) (ABIN8019764)

Target: Patched 2 (PTCH2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Patched 2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Patched 2 Antibody (HRP)

Binding Specificity: Middle Region

Purpose: Anti-PTCH2 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human PTCH2, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Patched 2

Target: Patched 2 (PTCH2)

Alternative Name: PTCH2

Background:

Background: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role forPtch2in adult epidermal homeostasis via Shh signaling.

Gene Full Name: patched 2

Gene ID: 8643

UniProt: Q9Y6C5

Pathways: Hedgehog Signaling