PGC antibody (AA 145-356) (HRP)

Catalog No. ABIN8020079

This Rabbit Polyclonal antibody specifically detects PGC in WB, IHC and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for PGC antibody (AA 145-356) (HRP) (ABIN8020079)

Target: PGC (Pepsinogen C (PGC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGC antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PGC Antibody (HRP)

Binding Specificity: AA 145-356

Purpose: Anti-PGC Antibody HRP Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PGC shares 69.5%,70% amino acid (aa) sequence identity with mouse,rat PGC,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PGC recombinant protein (Position: Y145-N356). Human PGC shares 69.5% and 70% amino acid (aa) sequence identity with mouse and rat PGC, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: PGC

Background:

Background: Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in humans is encoded by the PGC gene. This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene Full Name: progastricsin

Gene ID: 5225

UniProt: P20142