Peroxiredoxin 5 antibody (C-Term) (PE)

Catalog No. ABIN8020690

The PE-conjugated Rabbit Polyclonal anti-Peroxiredoxin 5 antibody (ABIN8020690) specifically detects Peroxiredoxin 5 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Peroxiredoxin 5 antibody (C-Term) (PE) (ABIN8020690)

Target: Peroxiredoxin 5 (PRDX5)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 5 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Peroxiredoxin 5 Antibody (PE)

Binding Specificity: C-Term

Purpose: Anti-Peroxiredoxin 5/PRDX5 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 5, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Peroxiredoxin 5

Target: Peroxiredoxin 5 (PRDX5)

Alternative Name: PRDX5

Background:

Background: PRDX5 (peroxiredoxin 5) also known as AOEB166, ACR1,B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10, is a member of the peroxiredoxin family and may play an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes. The PRDX5 gene is mapped on 11q13.1. PRDX5 displays mitochondrial presequence features and has 3 cysteines implicated in antioxidant activity and a C-terminal SQL peroxisomal targeting sequence. Northern blot analysis revealed ubiquitous expression of a 1.0-kb PRDX5 transcript in tissues and cell lines. Functional analysis showed that PRDX5 has antioxidant activity equivalent to that of CAT. While PRDX5 was localized to fibroblasts in normal tendon, it was localized to fibroblasts and endothelial cells in degenerative tendon. PRDX5 mRNA and protein levels increased at 12 hours, and the increase in PRDX5 expression correlated with reduced peroxide levels. PRDX5 plays a protective role against oxidative stress in human cartilage.

Gene Full Name: peroxiredoxin 5

Sequence Similarities: Belongs to the peroxiredoxin 2 family.

Gene ID: 25824

UniProt: P30044

Pathways: Cell RedoxHomeostasis