PEX19 antibody (AA 51-269) (Fluoro647)

Catalog No. ABIN8020770

The Rabbit Polyclonal anti-PEX19 antibody is suitable to detect PEX19 in samples from Human. It has been validated for FACS.

Quick Overview for PEX19 antibody (AA 51-269) (Fluoro647) (ABIN8020770)

Target: PEX19 (Peroxisomal Biogenesis Factor 19 (PEX19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEX19 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-PEX19 Antibody (Fluoro647)

Binding Specificity: AA 51-269

Purpose: Anti-PEX19 Antibody Fluoro647 Conjugated

Predicted Reactivity: Human PEX19 shares 91.8%,94.5% amino acid (aa) sequence identity with mouse,rat PEX19,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PEX19 recombinant protein (Position: Q51-A269). Human PEX19 shares 91.8% and 94.5% amino acid (aa) sequence identity with mouse and rat PEX19, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PEX19

Target: PEX19 (Peroxisomal Biogenesis Factor 19 (PEX19))

Alternative Name: PEX19

Background:

Background: Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene. This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.

Gene Full Name: peroxisomal biogenesis factor 19

Gene ID: 5824

UniProt: P40855