PHF8 antibody (AA 108-946) (HRP)

Catalog No. ABIN8021049

The Rabbit Polyclonal anti-PHF8 antibody is suitable to detect PHF8 in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for PHF8 antibody (AA 108-946) (HRP) (ABIN8021049)

Target: PHF8 (PHD Finger Protein 8 (PHF8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHF8 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PHF8 Antibody (HRP)

Binding Specificity: AA 108-946

Purpose: Anti-PHF8 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PHF8 shares 94.6% amino acid (aa) sequence identity with mouse PHF8.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PHF8 recombinant protein (Position: H108-D946). Human PHF8 shares 94.6% amino acid (aa) sequence identity with mouse PHF8.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PHF8

Target: PHF8 (PHD Finger Protein 8 (PHF8))

Alternative Name: PHF8

Background:

Background: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: PHD finger protein 8

Gene ID: 23133

UniProt: Q9UPP1