PDE4B antibody (AA 1-736) (Fluoro647)

Catalog No. ABIN8021443

The Fluoro647-conjugated Rabbit Polyclonal anti-PDE4B antibody (ABIN8021443) specifically detects PDE4B in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for PDE4B antibody (AA 1-736) (Fluoro647) (ABIN8021443)

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4B antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-PDE4B Antibody (Fluoro647)

Binding Specificity: AA 1-736

Purpose: Anti-PDE4B Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PDE4B shares 96.6% amino acid (aa) sequence identity with rat PDE4B.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PDE4B recombinant protein (Position: M1-T736). Human PDE4B shares 96.6% amino acid (aa) sequence identity with rat PDE4B.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PDE4B

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Alternative Name: PDE4B

Background:

Background: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

Gene Full Name: phosphodiesterase 4B

Gene ID: 5142

UniProt: Q07343

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction