PDE8A antibody (AA 32-495) (Fluoro488)

Catalog No. ABIN8021548

The Fluoro488-conjugated Rabbit Polyclonal anti-PDE8A antibody (ABIN8021548) specifically detects PDE8A in FACS. The antibody is reactive with Human samples.

Quick Overview for PDE8A antibody (AA 32-495) (Fluoro488) (ABIN8021548)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8A antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-PDE8A Antibody (Fluoro488)

Binding Specificity: AA 32-495

Purpose: Anti-PDE8A Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PDE8A shares 80.5% amino acid (aa) sequence identity with mouse PDE8A.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PDE8A recombinant protein (Position: R32-E495). Human PDE8A shares 80.5% amino acid (aa) sequence identity with mouse PDE8A.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Alternative Name: PDE8A

Background:

Background: High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: phosphodiesterase 8A

Gene ID: 5151

UniProt: O60658

Pathways: cAMP Metabolic Process