PDE8B antibody (C-Term) (Biotin)

Catalog No. ABIN8021558

This Rabbit Polyclonal antibody specifically detects PDE8B in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PDE8B antibody (C-Term) (Biotin) (ABIN8021558)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PDE8B Antibody (Biotin)

Binding Specificity: C-Term

Purpose: Anti-PDE8B Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PDE8B shares 100% amino acid (aa) sequence identity with mouse PDE8B.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PDE8B. Human PDE8B shares 100% amino acid (aa) sequence identity with mouse PDE8B.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B

Background:

Background: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: phosphodiesterase 8B

Gene ID: 8622

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process