PLA2G3 antibody (AA 74-358) (Biotin)

Catalog No. ABIN8022001

The Biotin-conjugated Rabbit Polyclonal anti-PLA2G3 antibody (ABIN8022001) specifically detects PLA2G3 in WB, IHC and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PLA2G3 antibody (AA 74-358) (Biotin) (ABIN8022001)

Target: PLA2G3 (Phospholipase A2, Group III (PLA2G3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G3 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PLA2G3 Antibody (Biotin)

Binding Specificity: AA 74-358

Purpose: Anti-PLA2G3 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PLA2G3 shares 66.8% amino acid (aa) sequence identity with mouse PLA2G3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLA2G3 recombinant protein (Position: E74-R358). Human PLA2G3 shares 66.8% amino acid (aa) sequence identity with mouse PLA2G3.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PLA2G3

Target: PLA2G3 (Phospholipase A2, Group III (PLA2G3))

Alternative Name: PLA2G3

Background:

Background: This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease.

Gene Full Name: phospholipase A2 group III

Gene ID: 50487

UniProt: Q9NZ20