PLD6 antibody (AA 39-238) (Fluoro488)

Catalog No. ABIN8022204

The Rabbit Polyclonal anti-PLD6 antibody is suitable to detect PLD6 in samples from Human. It has been validated for FACS.

Quick Overview for PLD6 antibody (AA 39-238) (Fluoro488) (ABIN8022204)

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLD6 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-PLD6 Antibody (Fluoro488)

Binding Specificity: AA 39-238

Purpose: Anti-PLD6 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLD6 recombinant protein (Position: R39-L238).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Alternative Name: PLD6

Background:

Background: PLD6 (phospholipase D family, member 6) is a protein-coding gene. Among its related super-pathways are choline biosynthesis III and Glycerophospholipid biosynthesis. GO annotations related to this gene include cardiolipin hydrolase activity and protein homodimerization activity. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could ly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.

Gene Full Name: phospholipase D family member 6

Gene ID: 201164

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization