PLD1 antibody (AA 1-330) (HRP)

Catalog No. ABIN8022219

The Rabbit Polyclonal anti-PLD1 antibody is suitable to detect PLD1 in samples from Human and Mouse. It has been validated for ELISA, WB and IHC.

Quick Overview for PLD1 antibody (AA 1-330) (HRP) (ABIN8022219)

Target: PLD1 (Phospholipase D1 (PLD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLD1 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PLD1 Antibody (HRP)

Binding Specificity: AA 1-330

Purpose: Anti-Phospholipase D1/PLD1 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human PLD1 shares 91.8%,90.9% amino acid (aa) sequence identity with mouse,rat PLD1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLD1 recombinant protein (Position: M1-H330). Human PLD1 shares 91.8% and 90.9% amino acid (aa) sequence identity with mouse and rat PLD1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PLD1

Target: PLD1 (Phospholipase D1 (PLD1))

Alternative Name: PLD1

Background:

Background: By somatic cell hybrid analysis, PLD1 is mapped to 3q26.31. This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. And PLD1 disrupted association of gamma-secretase protein components, independent of PLD1catalytic activity. What's more, PLD1 regulates intracellular trafficking of beta-amyloid, distinct from its effect on gamma-secretase activity.

Gene Full Name: phospholipase D1

Sequence Similarities: Belongs to the phospholipase D family.

Gene ID: 5337

UniProt: Q13393