PMM2 antibody (AA 48-246) (Fluoro647)

Catalog No. ABIN8022288

The Rabbit Polyclonal anti-PMM2 antibody is suitable to detect PMM2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for PMM2 antibody (AA 48-246) (Fluoro647) (ABIN8022288)

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMM2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-PMM2 Antibody (Fluoro647)

Binding Specificity: AA 48-246

Purpose: Anti-PMM2 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PMM2 shares 92.4% amino acid (aa) sequence identity with mouse PMM2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PMM2 recombinant protein (Position: D48-S246). Human PMM2 shares 92.4% amino acid (aa) sequence identity with mouse PMM2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PMM2

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Alternative Name: PMM2

Background:

Background: Phosphomannomutase 2 is an enzyme that in humans is encoded by the PMM2 gene. The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.

Gene Full Name: phosphomannomutase 2

Gene ID: 5373

UniProt: O15305