SERPINB2 antibody (AA 1-180) (Biotin)

Catalog No. ABIN8022868

The Biotin-conjugated Rabbit Polyclonal anti-SERPINB2 antibody (ABIN8022868) specifically detects SERPINB2 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for SERPINB2 antibody (AA 1-180) (Biotin) (ABIN8022868)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB2 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SERPINB2 Antibody (Biotin)

Binding Specificity: AA 1-180

Purpose: Anti-SerpinB2 Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human SerpinB2 shares 70%,66% amino acid (aa) sequence identity with mouse,rat SerpinB2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SerpinB2 recombinant protein (Position: M1-K180). Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Alternative Name: SERPINB2

Target Type: Amino Acid

Background:

Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60- kDa extracellular glycosylated form and a 43- kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Gene Full Name: serpin family B member 2

Sequence Similarities: Belongs to the semaphorin family.

Gene ID: 5055

UniProt: P05120

Pathways: Autophagy