SERPINB2 antibody (AA 1-180) (Fluoro594)

Catalog No. ABIN8022872

This Rabbit Polyclonal antibody specifically detects SERPINB2 in FACS. It exhibits reactivity toward Human.

Quick Overview for SERPINB2 antibody (AA 1-180) (Fluoro594) (ABIN8022872)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB2 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-SERPINB2 Antibody (Fluoro594)

Binding Specificity: AA 1-180

Purpose: Anti-SerpinB2 Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human SerpinB2 shares 70%,66% amino acid (aa) sequence identity with mouse,rat SerpinB2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SerpinB2 recombinant protein (Position: M1-K180). Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Alternative Name: SERPINB2

Target Type: Amino Acid

Background:

Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60- kDa extracellular glycosylated form and a 43- kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Gene Full Name: serpin family B member 2

Sequence Similarities: Belongs to the semaphorin family.

Gene ID: 5055

UniProt: P05120

Pathways: Autophagy