PRDM8 antibody (AA 14-405) (HRP)

Catalog No. ABIN8025000

The Rabbit Polyclonal anti-PRDM8 antibody is suitable to detect PRDM8 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for PRDM8 antibody (AA 14-405) (HRP) (ABIN8025000)

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM8 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PRDM8 Antibody (HRP)

Binding Specificity: AA 14-405

Purpose: Anti-PRDM8 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PRDM8 recombinant protein (Position: D14-D405).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PRDM8

Target: PRDM8 (PR Domain Containing 8 (PRDM8))

Alternative Name: PRDM8

Background:

Background: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants.

Gene Full Name: PR/SET domain 8

Gene ID: 56978

UniProt: Q9NQV8