PCMT1 antibody (AA 1-227) (HRP)

Catalog No. ABIN8028577

The HRP-conjugated Rabbit Polyclonal anti-PCMT1 antibody (ABIN8028577) specifically detects PCMT1 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PCMT1 antibody (AA 1-227) (HRP) (ABIN8028577)

Target: PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCMT1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PCMT1 Antibody (HRP)

Binding Specificity: AA 1-227

Purpose: Anti-PCMT1 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PCMT1 shares 96%,95.6% amino acid (aa) sequence identity with mouse,rat PCMT1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PCMT1 recombinant protein (Position: M1-K227). Human PCMT1 shares 96% and 95.6% amino acid (aa) sequence identity with mouse and rat PCMT1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PCMT1

Target: PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))

Alternative Name: PCMT1

Background:

Background: Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene. This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Full Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase

Gene ID: 5110

UniProt: P22061

Pathways: Ribonucleoprotein Complex Subunit Organization