PNP antibody (AA 44-273) (Fluoro647)

Catalog No. ABIN8028976

The Fluoro647-conjugated Rabbit Polyclonal anti-PNP antibody (ABIN8028976) specifically detects PNP in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for PNP antibody (AA 44-273) (Fluoro647) (ABIN8028976)

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNP antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-PNP Antibody (Fluoro647)

Binding Specificity: AA 44-273

Purpose: Anti-PNP Antibody Fluoro647 Conjugated

Predicted Reactivity: Human PNP shares 86.5%,87% amino acid (aa) sequence identity with mouse,rat PNP,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PNP recombinant protein (Position: Q44-Q273). Human PNP shares 86.5% and 87% amino acid (aa) sequence identity with mouse and rat PNP, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PNP

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Alternative Name: PNP

Background:

Background: The PNP gene encodes purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T?lymphocyte function and neurologic dysfunction.

Gene Full Name: purine nucleoside phosphorylase

Gene ID: 4860

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus