RGS18 antibody (AA 1-230) (PE)

Catalog No. ABIN8031219

The Rabbit Polyclonal anti-RGS18 antibody is suitable to detect RGS18 in samples from Human. It has been validated for FACS.

Quick Overview for RGS18 antibody (AA 1-230) (PE) (ABIN8031219)

Target: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS18 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-RGS18 Antibody (PE)

Binding Specificity: AA 1-230

Purpose: Anti-RGS18 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RGS18 recombinant protein (Position: M1-D230).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RGS18

Target: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Alternative Name: RGS18

Background:

Background: Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene. This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene Full Name: regulator of G protein signaling 18

Gene ID: 64407

UniProt: Q9NS28

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling