RTKN2 antibody (AA 1-572) (Fluoro488)

Catalog No. ABIN8032295

This Rabbit Polyclonal antibody specifically detects RTKN2 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RTKN2 antibody (AA 1-572) (Fluoro488) (ABIN8032295)

Target: RTKN2 (Rhotekin 2 (RTKN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RTKN2 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-RTKN2 Antibody (Fluoro488)

Binding Specificity: AA 1-572

Purpose: Anti-RTKN2 Antibody Fluoro488 Conjugated

Predicted Reactivity: Human RTKN2 shares 71.8% amino acid (aa) sequence identity with mouse RTKN2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RTKN2 recombinant protein (Position: M1-D572). Human RTKN2 shares 71.8% amino acid (aa) sequence identity with mouse RTKN2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RTKN2

Target: RTKN2 (Rhotekin 2 (RTKN2))

Alternative Name: RTKN2

Background:

Background: Rhotekin 2 is a protein in humans that is encoded by the RTKN2 gene. The RTKN2 gene encodes a protein known as Rhotekin-2, which is involved in various cellular processes, including cytoskeletal organization, cell migration, and signal transduction. RTKN2 interacts with Rho GTPases, particularly RhoA, and modulates their activity to regulate actin cytoskeleton dynamics and cell morphology. This protein plays a role in cell adhesion and migration, with implications for tissue development, wound healing, and cancer metastasis. Additionally, RTKN2 has been linked to synaptic plasticity and neuronal development in the brain. Dysregulation of RTKN2 expression or function has been associated with neurological disorders, cardiovascular diseases, and cancer progression. Elucidating the molecular mechanisms underlying RTKN2's diverse functions is crucial for understanding its physiological roles and its potential as a therapeutic target for various diseases.

Gene Full Name: rhotekin 2

Gene ID: 219790

UniProt: Q8IZC4