RNF20 antibody (AA 123-389) (Fluoro647)

Catalog No. ABIN8033260

The Fluoro647-conjugated Mouse Monoclonal anti-RNF20 antibody (Clone 3C6E2) (ABIN8033260) specifically detects RNF20 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RNF20 antibody (AA 123-389) (Fluoro647) (ABIN8033260)

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNF20 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Clone: 3C6E2

Product Details anti-RNF20 Antibody (Fluoro647)

Binding Specificity: AA 123-389

Purpose: Anti-RNF20 Antibody (monoclonal, 3C6E2) Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RNF20 recombinant protein (Position: E123-S389).

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RNF20

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Alternative Name: RNF20

Background:

Background: E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).

Gene Full Name: ring finger protein 20

Gene ID: 56254

UniProt: Q5VTR2