SAV1 antibody (AA 8-320) (PE)

Catalog No. ABIN8034478

The PE-conjugated Rabbit Polyclonal anti-SAV1 antibody (ABIN8034478) specifically detects SAV1 in FACS. The antibody is reactive with Human samples.

Quick Overview for SAV1 antibody (AA 8-320) (PE) (ABIN8034478)

Target: SAV1 (Salvador Homolog 1 (SAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAV1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-SAV1 Antibody (PE)

Binding Specificity: AA 8-320

Purpose: Anti-SAV1 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SAV1 recombinant protein (Position: K8-H320).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SAV1

Target: SAV1 (Salvador Homolog 1 (SAV1))

Alternative Name: SAV1

Background:

Background: Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Gene Full Name: salvador family WW domain containing protein 1

Gene ID: 60485

UniProt: Q9H4B6

Pathways: Stem Cell Maintenance