SAV1 antibody (AA 8-320)

Catalog No. ABIN8034480

The Rabbit Polyclonal anti-SAV1 antibody is suitable to detect SAV1 in samples from Human. It has been validated for WB, ELISA, IHC and FACS.

Quick Overview for SAV1 antibody (AA 8-320) (ABIN8034480)

Target: SAV1 (Salvador Homolog 1 (SAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-SAV1 Antibody

Binding Specificity: AA 8-320

Purpose: Anti-SAV1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SAV1 Antibody. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SAV1 recombinant protein (Position: K8-H320).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SAV1

Target: SAV1 (Salvador Homolog 1 (SAV1))

Alternative Name: SAV1

Background:

Background: Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Gene Full Name: salvador family WW domain containing protein 1

Molecular Weight: 45 kDa

Gene ID: 60485

UniProt: Q9H4B6

Pathways: Stem Cell Maintenance