SEC31A antibody (AA 101-806) (Fluoro647)

Catalog No. ABIN8034986

This Rabbit Polyclonal antibody specifically detects SEC31A in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SEC31A antibody (AA 101-806) (Fluoro647) (ABIN8034986)

Target: SEC31A (SEC31 Homolog A (SEC31A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC31A antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-SEC31A Antibody (Fluoro647)

Binding Specificity: AA 101-806

Purpose: Anti-SEC31A Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SEC31A recombinant protein (Position: Y101-K806).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SEC31A

Target: SEC31A (SEC31 Homolog A (SEC31A))

Alternative Name: SEC31A

Background:

Background: Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene. The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: SEC31 homolog A, COPII component

Gene ID: 22872

UniProt: O94979

Pathways: ER-Nucleus Signaling