SEC63 antibody (AA 37-760) (APC)

Catalog No. ABIN8035017

The Rabbit Polyclonal anti-SEC63 antibody is suitable to detect SEC63 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for SEC63 antibody (AA 37-760) (APC) (ABIN8035017)

Target: SEC63 (SEC63 Homolog (SEC63))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC63 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SEC63 Antibody (APC)

Binding Specificity: AA 37-760

Purpose: Anti-SEC63 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SEC63 shares 96.1% amino acid (aa) sequence identity with mouse SEC63.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SEC63 recombinant protein (Position: R37-D760). Human SEC63 shares 96.1% amino acid (aa) sequence identity with mouse SEC63.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SEC63

Target: SEC63 (SEC63 Homolog (SEC63))

Alternative Name: SEC63

Background:

Background: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Gene Full Name: SEC63 protein translocation regulator

Gene ID: 11231

UniProt: Q9UGP8

Pathways: ER-Nucleus Signaling