SECISBP2 antibody (AA 12-854)

Catalog No. ABIN8035053

The Rabbit Polyclonal anti-SECISBP2 antibody is suitable to detect SECISBP2 in samples from Human. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for SECISBP2 antibody (AA 12-854) (ABIN8035053)

Target: SECISBP2 (SECIS Binding Protein 2 (SECISBP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SECISBP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Grade: Carrier-free

Product Details anti-SECISBP2 Antibody

Binding Specificity: AA 12-854

Purpose: Anti-SECISBP2 Antibody

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human SECISBP2 shares 71.7% amino acid (aa) sequence identity with rat SECISBP2.

Characteristics: Anti-SECISBP2 Antibody. Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SECISBP2 recombinant protein (Position: E12-L854). Human SECISBP2 shares 71.7% amino acid (aa) sequence identity with rat SECISBP2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SECISBP2

Target: SECISBP2 (SECIS Binding Protein 2 (SECISBP2))

Alternative Name: SECISBP2

Background:

Background: SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene. The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element, present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: SECIS binding protein 2

Molecular Weight: 105 kDa

Gene ID: 79048

UniProt: Q96T21