Secretin antibody (AA 25-65) (Fluoro488)

Catalog No. ABIN8035199

This Rabbit Polyclonal antibody specifically detects Secretin in FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for Secretin antibody (AA 25-65) (Fluoro488) (ABIN8035199)

Target: Secretin (SECR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Secretin antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Secretin Antibody (Fluoro488)

Binding Specificity: AA 25-65

Purpose: Anti-Secretin/Sct Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Secretin/Sct recombinant protein (Position: A25-D65).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Secretin

Target: Secretin (SECR)

Alternative Name: Sct

Background:

Background: Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene. This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone.

Gene Full Name: secretin

Gene ID: 20287

UniProt: Q08535

Pathways: Stem Cell Maintenance