SEZ6L antibody (AA 662-953) (Fluoro550)

Catalog No. ABIN8035277

This Rabbit Polyclonal antibody specifically detects SEZ6L in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SEZ6L antibody (AA 662-953) (Fluoro550) (ABIN8035277)

Target: SEZ6L (Seizure Related 6 Homolog Like (SEZ6L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEZ6L antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-SEZ6L Antibody (Fluoro550)

Binding Specificity: AA 662-953

Purpose: Anti-SEZ6L Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SEZ6L recombinant protein (Position: E662-E953).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SEZ6L

Target: SEZ6L (Seizure Related 6 Homolog Like (SEZ6L))

Alternative Name: SEZ6L

Background:

Background: Seizure 6-like protein is a protein that in humans is encoded by the SEZ6L gene. SEZ6L (Seizure 6-Like protein, also BSRP-B in rodent) is a 200 kDa member of the SEZ6 family of proteins. It is expressed in the plasma membrane and ER of CNS neurons and lung bronchiolar epithelium, and likely regulates PKC alpha activation. Mature human SEZ6L is a 996 amino acid (aa) type I transmembrane protein. It contains a 930 aa extracellular domain (ECD) (aa 29-958) plus a 45 aa cytoplasmic tail. The ECD shows three CUB domains and five short consensus repeats (SCRs). There are multiple isoforms possible for SEZ6L. One shows a deletion of aa 933-943, and a second shows the same deletion coupled to a Thr substitution for aa 803-867. A third isoform contains a Leu substitution for aa 867-943. An alternative start site is reported at Met228. This start site may occur individually, or be accompanied by a deletion of aa 932-944, the same deletion of aa 932-944 coupled to a Thr substitution for aa 803-867, or a duel deletion of aa 869-945 and 1016-1024. Over aa 29-958, human BSRP-B is 80 % aa identical to mouse BSRP-B.

Gene Full Name: seizure related 6 homolog like

Gene ID: 23544

UniProt: Q9BYH1