SPR antibody (AA 36-261) (Cy3)

Catalog No. ABIN8035639

The Cy3-conjugated Rabbit Polyclonal anti-SPR antibody (ABIN8035639) specifically detects SPR in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for SPR antibody (AA 36-261) (Cy3) (ABIN8035639)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-SPR Antibody (Cy3)

Binding Specificity: AA 36-261

Purpose: Anti-SPR Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SPR recombinant protein (Position: V36-K261).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR

Background:

Background: Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Gene Full Name: sepiapterin reductase

Gene ID: 6697

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration