SPR antibody (AA 36-261)

Catalog No. ABIN8035648

The Rabbit Polyclonal anti-SPR antibody (ABIN8035648) specifically detects SPR in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SPR antibody (AA 36-261) (ABIN8035648)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-SPR Antibody

Binding Specificity: AA 36-261

Purpose: Anti-SPR Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SPR Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SPR recombinant protein (Position: V36-K261).

Isotype: IgG

Application Details

Application Notes: Western blot,0.1-0.5 μg/mL ELISA,0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR

Background:

Background: Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Gene Full Name: sepiapterin reductase

Molecular Weight: 28 kDa

Gene ID: 6697

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration