STK4 antibody (AA 324-452) (Fluoro647)

Catalog No. ABIN8036135

This Rabbit Polyclonal antibody specifically detects STK4 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STK4 antibody (AA 324-452) (Fluoro647) (ABIN8036135)

Target: STK4 (serine/threonine Kinase 4 (STK4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK4 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-STK4 Antibody (Fluoro647)

Binding Specificity: AA 324-452

Purpose: Anti-MST1/STK4 Antibody Fluoro647 Conjugated

Predicted Reactivity: Human STK4 shares 93.8% amino acid (aa) sequence identity with mouse STK4.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MST1/STK4 recombinant protein (Position: E324-D452). Human STK4 shares 93.8% amino acid (aa) sequence identity with mouse STK4.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Alternative Name: MST1/STK4

Background:

Background: Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Gene Full Name: serine/threonine kinase 4

Gene ID: 6789

UniProt: Q13043

Pathways: Tube Formation