SESN1 antibody (AA 1-275) (APC)

Catalog No. ABIN8036652

The Rabbit Polyclonal anti-SESN1 antibody is suitable to detect SESN1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for SESN1 antibody (AA 1-275) (APC) (ABIN8036652)

Target: SESN1 (Sestrin 1 (SESN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SESN1 Antibody (APC)

Binding Specificity: AA 1-275

Purpose: Anti-SESN1 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SESN1 recombinant protein (Position: M1-A275).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: SESN1

Background:

Background: Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Full Name: sestrin 1

Gene ID: 27244

UniProt: Q9Y6P5