SETDB1 antibody (AA 20-871) (Fluoro647)

Catalog No. ABIN8036753

This Rabbit Polyclonal antibody specifically detects SETDB1 in FACS. It exhibits reactivity toward Human.

Quick Overview for SETDB1 antibody (AA 20-871) (Fluoro647) (ABIN8036753)

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETDB1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-SETDB1 Antibody (Fluoro647)

Binding Specificity: AA 20-871

Purpose: Anti-SETDB1 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SETDB1 shares 92.9% amino acid (aa) sequence identity with mouse SETDB1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SETDB1 recombinant protein (Position: E20-E871). Human SETDB1 shares 92.9% amino acid (aa) sequence identity with mouse SETDB1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SETDB1

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Alternative Name: SETDB1

Background:

Background: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene Full Name: SET domain bifurcated histone lysine methyltransferase 1

Gene ID: 9869

UniProt: Q15047